{"id":1956,"date":"2024-06-28T06:43:09","date_gmt":"2024-06-28T05:43:09","guid":{"rendered":"https:\/\/medreasons.com\/?page_id=1956"},"modified":"2024-07-02T06:59:11","modified_gmt":"2024-07-02T05:59:11","slug":"role-of-acth-in-infantile-spasms","status":"publish","type":"page","link":"https:\/\/medreasons.com\/index.php\/posts\/paediatrics\/central-nervous-system\/role-of-acth-in-infantile-spasms\/","title":{"rendered":"Role of ACTH in Infantile Spasms"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1956\" class=\"elementor elementor-1956\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-24b9cf0 e-flex e-con-boxed e-con e-parent\" data-id=\"24b9cf0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-94830f9 e-flex e-con-boxed e-con e-child\" data-id=\"94830f9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-309a89c elementor-widget elementor-widget-text-editor\" data-id=\"309a89c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1>Role of ACTH in Infantile Spasms<\/h1>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8226513 elementor-widget elementor-widget-text-editor\" data-id=\"8226513\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Infantile Spasms are brief episodes of seizure in an infant and is usually associated with West Syndrome. It usually occurs between 4 to 12 months of age and usually resolves by 2 years. Hence the mainstay of treatment is to control the seizures.<\/p><p>Adrenocorticotropic hormone (ACTH), a peptide hormone secreted by the anterior pituitary acts on the adrenal gland to release cortisol and androgens. ACTH injections are used for rapid and complete elimination of infantile spasms.\u00a0\u00a0<\/p><p>Mechanism of action of ACTH in Infantile spasms is based on &#8211;\u00a0\u00a0<\/p><ul><li><span style=\"text-decoration: underline;\"><strong>common excitatory pathway<\/strong><\/span><strong> :<\/strong> Increased (CRH) synthesis in limbic system activates the native stress system of brain and causes seizures. ACTH decreases the production and release of CRH (Corticotropin hormone) in limbic system.\u00a0\u00a0<\/li><li><span style=\"text-decoration: underline;\"><strong>direct<\/strong><\/span><span style=\"font-size: 16px;\"><span style=\"text-decoration: underline;\"><strong> influence on limbic neurons<\/strong><\/span> via the recently characterized melanocortin receptors.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f73198 elementor-post-navigation-borders-yes elementor-widget elementor-widget-post-navigation\" data-id=\"9f73198\" data-element_type=\"widget\" data-widget_type=\"post-navigation.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-post-navigation\">\n\t\t\t<div class=\"elementor-post-navigation__prev elementor-post-navigation__link\">\n\t\t\t\t<a href=\"https:\/\/medreasons.com\/index.php\/posts\/anatomy\/neuroanatomy\/\" rel=\"prev\"><span class=\"post-navigation__arrow-wrapper post-navigation__arrow-prev\"><i class=\"fa fa-chevron-circle-left\" aria-hidden=\"true\"><\/i><span class=\"elementor-screen-only\">Prev<\/span><\/span><span class=\"elementor-post-navigation__link__prev\"><span class=\"post-navigation__prev--label\">Previous<\/span><span class=\"post-navigation__prev--title\">Neuroanatomy<\/span><\/span><\/a>\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-post-navigation__separator-wrapper\">\n\t\t\t\t\t<div class=\"elementor-post-navigation__separator\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-post-navigation__next elementor-post-navigation__link\">\n\t\t\t\t<a href=\"https:\/\/medreasons.com\/index.php\/posts\/pathology\/her2neu-and-breast-cancer\/\" rel=\"next\"><span class=\"elementor-post-navigation__link__next\"><span class=\"post-navigation__next--label\">Next<\/span><span class=\"post-navigation__next--title\">Her2neu and Breast Cancer<\/span><\/span><span class=\"post-navigation__arrow-wrapper post-navigation__arrow-next\"><i class=\"fa fa-chevron-circle-right\" aria-hidden=\"true\"><\/i><span class=\"elementor-screen-only\">Next<\/span><\/span><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9f4f1c2 e-flex e-con-boxed e-con e-child\" data-id=\"9f4f1c2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-297bf08 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"297bf08\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;xMidYMid meet&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 126 26&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M10.7,6l2.5,2.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L0.7,17L4,13.1L0,8.6l2.3-1.3l3.9,3.9L10.7,6z M23.9,6.6l4.2,4.5L32,7.2l2.3,1.3l-4,4.5l3.2,3.9L32,19.1l-3.9-3.3l-4.5,4.3l-2.5-1.9l4.4-5.1l-4.2-3.9L23.9,6.6zM73.5,6L76,8.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L63.5,17l4.1-4.7L63.5,8l2.3-1.3l4.1,3.6L73.5,6z M94,6l2.5,2.6l-4,4.3l4,5.4L94,20.1l-3.9-5l-3.9,4.2L84,17l3.2-3.9L84,8.6l2.3-1.3l3.2,3.9L94,6z M106.9,6l4.5,5.1l3.9-3.9l2.3,1.3l-4,4.5l3.2,3.9l-1.6,2.1l-3.9-4.2l-4.5,5.2l-2.5-1.9l4-5.4l-4-4.3L106.9,6z M53.1,6l2.5,2.6l-4,4.3l4,4.6l-2.5,1.9l-4.5-4.5l-3.5,4.5L43.1,17l3.2-3.9l-4-4.5l2.3-1.3l3.9,3.9L53.1,6z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Role of ACTH in Infantile Spasms Infantile Spasms are brief episodes of seizure in an infant and is usually associated with West Syndrome. It usually occurs between 4 to 12 months of age and usually resolves by 2 years. Hence the mainstay of treatment is to control the seizures. Adrenocorticotropic hormone (ACTH), a peptide hormone [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1633,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1956","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/comments?post=1956"}],"version-history":[{"count":37,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1956\/revisions"}],"predecessor-version":[{"id":2013,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1956\/revisions\/2013"}],"up":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1633"}],"wp:attachment":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/media?parent=1956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}