{"id":1726,"date":"2024-03-26T06:15:39","date_gmt":"2024-03-26T06:15:39","guid":{"rendered":"https:\/\/medreasons.com\/?page_id=1726"},"modified":"2024-03-28T03:51:30","modified_gmt":"2024-03-28T03:51:30","slug":"laxatives","status":"publish","type":"page","link":"https:\/\/medreasons.com\/index.php\/posts\/pharmacology\/git\/laxatives\/","title":{"rendered":"Laxatives"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1726\" class=\"elementor elementor-1726\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5ee6c91 e-flex e-con-boxed e-con e-parent\" data-id=\"5ee6c91\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-418159c elementor-widget elementor-widget-text-editor\" data-id=\"418159c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1>Senna and Melanosis Coli<\/h1>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca1c750 elementor-widget elementor-widget-text-editor\" data-id=\"ca1c750\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Laxatives are not needed by majority of people; yet they are self-prescribed by a large group of population. Long term laxative use can lead to various health issues. Let&#8217;s discuss about the side effect of one such laxative &#8211; &#8216;Senna&#8217;.\u00a0<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89a76ef elementor-widget elementor-widget-text-editor\" data-id=\"89a76ef\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Senna is a anthraquinone derivative from senna plant. Senna in Arabic refers to &#8216;laxative plant&#8217;.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-634dec7 elementor-widget elementor-widget-text-editor\" data-id=\"634dec7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Senna is used as a stimulant laxative which induces bowel movements by directly stimulating the enteric nervous system and by releasing colonic electrolytes and fluids. Senna is poorly absorbed in the large bowel where it is hydrolyzed by the colonic bacteria into its active moeities which irritate the colon promoting peristalsis and evacuation of bowel.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9541357 elementor-widget elementor-widget-image\" data-id=\"9541357\" data-element_type=\"widget\" a=\"\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"221\" src=\"https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/Anthraquinone-glycosides-sennosides-present-in-senna-leaves-For-sennoside-A-RCOOH-300x221.png\" class=\"attachment-medium size-medium wp-image-1746\" alt=\"\" srcset=\"https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/Anthraquinone-glycosides-sennosides-present-in-senna-leaves-For-sennoside-A-RCOOH-300x221.png 300w, https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/Anthraquinone-glycosides-sennosides-present-in-senna-leaves-For-sennoside-A-RCOOH.png 729w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Sennoside - Active principle of senna<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b827d02 elementor-widget elementor-widget-text-editor\" data-id=\"b827d02\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Chronic use of senna leads to a characteristic brown pigmentation of the colon known as Melanosis Coli.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6052565 elementor-widget elementor-widget-image\" data-id=\"6052565\" data-element_type=\"widget\" drkeithsiau=\"\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"245\" src=\"https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/melanosis-coli-300x245.jpg\" class=\"attachment-medium size-medium wp-image-1769\" alt=\"\" srcset=\"https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/melanosis-coli-300x245.jpg 300w, https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/melanosis-coli-1024x838.jpg 1024w, https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/melanosis-coli-768x628.jpg 768w, https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/melanosis-coli.jpg 1318w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Melanosis Coli <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20f8da3 elementor-widget elementor-widget-text-editor\" data-id=\"20f8da3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The active moieties of senna cause cell damage in the colon. During cell death, there is lipofuscin deposition. Lipofuscin is a dark pigment composed of oxidated residues of unsaturated fatty acids from cell membranes(The term melanosis is actually a misnomer as there is no melanin deposition). This pigment is eaten up by macrophages of the lamina propria which is visible as a dark pigmentation on colonoscopy and resolves after stopping the drug.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ec7a3fa e-flex e-con-boxed e-con e-parent\" data-id=\"ec7a3fa\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-38b63cf elementor-post-navigation-borders-yes elementor-widget elementor-widget-post-navigation\" data-id=\"38b63cf\" data-element_type=\"widget\" data-widget_type=\"post-navigation.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-post-navigation\">\n\t\t\t<div class=\"elementor-post-navigation__prev elementor-post-navigation__link\">\n\t\t\t\t<a href=\"https:\/\/medreasons.com\/index.php\/posts\/psychiatry\/child-psychiatry\/\" rel=\"prev\"><span class=\"post-navigation__arrow-wrapper post-navigation__arrow-prev\"><i class=\"fa fa-chevron-circle-left\" aria-hidden=\"true\"><\/i><span class=\"elementor-screen-only\">Prev<\/span><\/span><span class=\"elementor-post-navigation__link__prev\"><span class=\"post-navigation__prev--label\">Previous<\/span><span class=\"post-navigation__prev--title\">Child Psychiatry<\/span><\/span><\/a>\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-post-navigation__separator-wrapper\">\n\t\t\t\t\t<div class=\"elementor-post-navigation__separator\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-post-navigation__next elementor-post-navigation__link\">\n\t\t\t\t<a href=\"https:\/\/medreasons.com\/index.php\/posts\/pharmacology\/git\/mucosal-protective-agents\/\" rel=\"next\"><span class=\"elementor-post-navigation__link__next\"><span class=\"post-navigation__next--label\">Next<\/span><span class=\"post-navigation__next--title\">Mucosal Protective Agents<\/span><\/span><span class=\"post-navigation__arrow-wrapper post-navigation__arrow-next\"><i class=\"fa fa-chevron-circle-right\" aria-hidden=\"true\"><\/i><span class=\"elementor-screen-only\">Next<\/span><\/span><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Senna and Melanosis Coli Laxatives are not needed by majority of people; yet they are self-prescribed by a large group of population. Long term laxative use can lead to various health issues. Let&#8217;s discuss about the side effect of one such laxative &#8211; &#8216;Senna&#8217;.\u00a0 Senna is a anthraquinone derivative from senna plant. Senna in Arabic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":590,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1726","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1726","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/comments?post=1726"}],"version-history":[{"count":52,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1726\/revisions"}],"predecessor-version":[{"id":1796,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1726\/revisions\/1796"}],"up":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/590"}],"wp:attachment":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/media?parent=1726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}