{"id":1644,"date":"2024-03-23T02:39:22","date_gmt":"2024-03-23T02:39:22","guid":{"rendered":"https:\/\/medreasons.com\/?page_id=1644"},"modified":"2024-03-26T05:59:54","modified_gmt":"2024-03-26T05:59:54","slug":"child-psychiatry","status":"publish","type":"page","link":"https:\/\/medreasons.com\/index.php\/posts\/psychiatry\/child-psychiatry\/","title":{"rendered":"Child Psychiatry"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1644\" class=\"elementor elementor-1644\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c002ad e-flex e-con-boxed e-con e-parent\" data-id=\"8c002ad\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7748de2 elementor-widget elementor-widget-text-editor\" data-id=\"7748de2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1>Pathophysiology of Rett Syndrome<\/h1>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26d7f7e elementor-widget elementor-widget-text-editor\" data-id=\"26d7f7e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Children are lovable! It is pleasing to play with them and talk to them. But have you come across any child who repeatedly squeezes\/rubs\/claps\/flaps their hands most of the time so much so that it appears a little irky. This child might be a suffering from Rett Syndrome. <\/strong><\/p><p>Let&#8217;s decipher how Rett Syndrome occurs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9c30c6 elementor-widget elementor-widget-text-editor\" data-id=\"b9c30c6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Rett Syndrome named after Sir Andreas Rett, is a neurodevelopmental disorder associated with regression of milestones acquired in early life.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb59752 elementor-widget elementor-widget-image\" data-id=\"fb59752\" data-element_type=\"widget\" by=\"\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"225\" height=\"300\" src=\"https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/Rett_Girl_Smiling-225x300.jpg\" class=\"attachment-medium size-medium wp-image-1700\" alt=\"\" srcset=\"https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/Rett_Girl_Smiling-225x300.jpg 225w, https:\/\/medreasons.com\/wp-content\/uploads\/2024\/03\/Rett_Girl_Smiling.jpg 768w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Girl suffering from Rett Syndrome<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b0fae9 elementor-widget elementor-widget-text-editor\" data-id=\"4b0fae9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>To understand the pathophysiology of Rett syndrome we need to understand a little about a gene called MECP2 which codes for a protein MECP2. <strong>MECP2<\/strong> stands for <strong>M<\/strong>ethyl <strong>C<\/strong>p<strong>G<\/strong> binding <strong>P<\/strong>rotein &#8211; <strong>2. <\/strong>This protein has a unique methyl CpG binding domain which binds to regions containing 5 methyl-Cytosine and causes transcription or repression of the specific DNA region. It is found in high quantity in neurons and is associated with normal functioning of CNS and synaptic contact formation.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-04d34b7 elementor-widget elementor-widget-text-editor\" data-id=\"04d34b7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The problem starts with a inactivating mutation in MECP2 gene which follows a X linked Dominance pattern of inheritance. Although it is not clear how these inactivating mutations of MECP2 cause Rett syndrome but it has been proposed that MECP2 mutations affect the neuronal maturation in the following ways &#8211;<\/p><ul><li><strong>Delayed synaptic maturation : <\/strong>failure of arborization formation in the cortex leads to abnormal signaling and abnormal development of Autonomic nervous system along with motor and cortical tissues and glial tissues. This explains why children with rett syndrome have <strong>postnatal deceleration in head growth.<\/strong><\/li><li><strong>Disruption of Cholesterol metabolism<\/strong> leads to abnormal neuronal development.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db69967 elementor-widget elementor-widget-text-editor\" data-id=\"db69967\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Pathophysiology behind <span style=\"text-decoration: underline;\">stereotypy of hand movements<\/span>\u00a0in Rett Syndrome<\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52031cc elementor-widget elementor-widget-text-editor\" data-id=\"52031cc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Rett Syndrome is characterized by stereotypy of hand movements such as wringing, tapping, licking, washing. These non purposeful movements are a result of loss of normal acquired purposeful movements of hands which get replaced by stereotypical movements.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef01185 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ef01185\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;xMidYMid meet&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 126 26&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M10.7,6l2.5,2.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L0.7,17L4,13.1L0,8.6l2.3-1.3l3.9,3.9L10.7,6z M23.9,6.6l4.2,4.5L32,7.2l2.3,1.3l-4,4.5l3.2,3.9L32,19.1l-3.9-3.3l-4.5,4.3l-2.5-1.9l4.4-5.1l-4.2-3.9L23.9,6.6zM73.5,6L76,8.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L63.5,17l4.1-4.7L63.5,8l2.3-1.3l4.1,3.6L73.5,6z M94,6l2.5,2.6l-4,4.3l4,5.4L94,20.1l-3.9-5l-3.9,4.2L84,17l3.2-3.9L84,8.6l2.3-1.3l3.2,3.9L94,6z M106.9,6l4.5,5.1l3.9-3.9l2.3,1.3l-4,4.5l3.2,3.9l-1.6,2.1l-3.9-4.2l-4.5,5.2l-2.5-1.9l4-5.4l-4-4.3L106.9,6z M53.1,6l2.5,2.6l-4,4.3l4,4.6l-2.5,1.9l-4.5-4.5l-3.5,4.5L43.1,17l3.2-3.9l-4-4.5l2.3-1.3l3.9,3.9L53.1,6z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-002681f elementor-post-navigation-borders-yes elementor-widget elementor-widget-post-navigation\" data-id=\"002681f\" data-element_type=\"widget\" data-widget_type=\"post-navigation.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-post-navigation\">\n\t\t\t<div class=\"elementor-post-navigation__prev elementor-post-navigation__link\">\n\t\t\t\t<a href=\"https:\/\/medreasons.com\/index.php\/posts\/paediatrics\/central-nervous-system\/\" rel=\"prev\"><span class=\"post-navigation__arrow-wrapper post-navigation__arrow-prev\"><i class=\"fa fa-chevron-circle-left\" aria-hidden=\"true\"><\/i><span class=\"elementor-screen-only\">Prev<\/span><\/span><span class=\"elementor-post-navigation__link__prev\"><span class=\"post-navigation__prev--label\">Previous<\/span><span class=\"post-navigation__prev--title\">Central Nervous System<\/span><\/span><\/a>\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-post-navigation__separator-wrapper\">\n\t\t\t\t\t<div class=\"elementor-post-navigation__separator\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-post-navigation__next elementor-post-navigation__link\">\n\t\t\t\t<a href=\"https:\/\/medreasons.com\/index.php\/posts\/pharmacology\/git\/laxatives\/\" rel=\"next\"><span class=\"elementor-post-navigation__link__next\"><span class=\"post-navigation__next--label\">Next<\/span><span class=\"post-navigation__next--title\">Laxatives<\/span><\/span><span class=\"post-navigation__arrow-wrapper post-navigation__arrow-next\"><i class=\"fa fa-chevron-circle-right\" aria-hidden=\"true\"><\/i><span class=\"elementor-screen-only\">Next<\/span><\/span><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pathophysiology of Rett Syndrome Children are lovable! It is pleasing to play with them and talk to them. But have you come across any child who repeatedly squeezes\/rubs\/claps\/flaps their hands most of the time so much so that it appears a little irky. This child might be a suffering from Rett Syndrome. Let&#8217;s decipher how [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":132,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1644","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1644","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/comments?post=1644"}],"version-history":[{"count":58,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1644\/revisions"}],"predecessor-version":[{"id":1713,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/1644\/revisions\/1713"}],"up":[{"embeddable":true,"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/pages\/132"}],"wp:attachment":[{"href":"https:\/\/medreasons.com\/index.php\/wp-json\/wp\/v2\/media?parent=1644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}